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Depending on the severity and location of the nerve damage, this condition can lead to symptoms such as numbness, tingling, burning sensations, or facial pain [1]
10.1016/j.jacc.2018.03.002 7 BruceC
Several mechanisms have been proposed to explain chronic hyperglycemia-induced nerve damage, such as intracellular accumulation of sorbitol, glycation reactions, and oxidative and nitrosative stress (reviewed in 69)
Arch Biochem Biophys 180:248257 Murphy MP (2009) How mitochondria produce reactive oxygen species
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